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Luke obtained his BDS from Sydney University in 1984. He worked in private practice from 1985 until 1992 and became involved in implant dentistry in London in 1989. Luke attended the Royal Dental College Aarhus, Denmark from 1993 until 1996 obtaining a Masters Degree in Periodontology and receiving specialist registration as a Periodontist in NSW in the same year.He has been in private specialist practice in Sydney since 1996 and has extensive experience in implant dentistry.

Luke has published in several international journals and has lectured extensively at both the undergraduate and post graduate level. Luke was a lecturer in Periodotology at the University of Sydney from 1997 to 2008. He is now head of the Postgraduate Diploma of Dental Implantology program for Charles Sturt University.